The role of reciprocal activation of cAbl and Mst1 in the oxidative death of cultured astrocytes.

@article{Lee2014TheRO,
  title={The role of reciprocal activation of cAbl and Mst1 in the oxidative death of cultured astrocytes.},
  author={Sook-Jeong Lee and B C Seo and Eui-Ju Choi and Jae-Young Koh},
  journal={Glia},
  year={2014},
  volume={62 4},
  pages={639-48}
}
The protein kinase Mst1 (mammalian Sterile 20-like kinase 1) likely plays a role in oxidative neuronal cell death as a target of its activator, cAbl. We previously found that H2O2-induced death of astrocytes is mediated by cAbl in a metallothionein-3 (Mt3)-dependent manner. In the present study, we examined a possible role for Mst1 in the oxidative death of astrocytes. Treatment of cortical astrocytes with 170 µM H2O2 activated Mst1. Knockdown of Mst1 reduced H2O2-induced cell death, indicating… CONTINUE READING
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