The role of receptor subtype diversity in the CNS.


The molecular characterization of neuroreceptors and voltage-gated ion channels has revealed that receptor subtype heterogeneity is a common feature of chemical and electrical signal reception. The use of distinct genes encoding receptor subtypes is a favoured mechanism for generation of this diversity. We propose that the significance of the multiplicity and diversity of signal reception proteins is to increase the information-handling capacity of neurons. This may contribute to neural plasticity.


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@article{Schofield1990TheRO, title={The role of receptor subtype diversity in the CNS.}, author={Peter R. Schofield and B. D. Shivers and P. H. Seeburg}, journal={Trends in neurosciences}, year={1990}, volume={13 1}, pages={8-11} }