The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis.

@article{Brenner2003TheRO,
  title={The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis.},
  author={Talma Brenner and Yasmine Hamra-Amitay and Tama Evron and Neli Boneva and Shlomo Seidman and Hermona Soreq},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 2},
  pages={214-22}
}
Alternative splicing induces, under abnormal cholinergic neurotransmission, overproduction of the rare "readthrough" acetylcholinesterase variant AChE-R. We explored the pathophysiological relevance of this phenomenon in patients with myasthenia gravis (MG) and rats with experimental autoimmune MG (EAMG), neuromuscular junction diseases with depleted acetylcholine receptors. In MG and EAMG, we detected serum AChE-R accumulation. In EAMG, we alleviated electromyographic abnormalities by… CONTINUE READING
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Immunology of the neuromuscular junction and presynaptic nerve terminal

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  • Curr. Opin. Neurol
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