The role of reactive oxygen species in thromboxane b2 generation by polymorphonuclear leukocytes.

@article{Segal1983TheRO,
  title={The role of reactive oxygen species in thromboxane b2 generation by polymorphonuclear leukocytes.},
  author={Mark Segal and Richard H. Fertel and Eric H. Kraut and Arthur L. Sagone},
  journal={The Journal of laboratory and clinical medicine},
  year={1983},
  volume={102 5},
  pages={788-94}
}
These studies evaluated further the relationship between the metabolism of reactive oxygen species (ROS) and prostaglandins in human granulocytes. Our experiments examined (1) the effects of several scavengers of ROS on thromboxane B2 (TXB2) production by zymosan-stimulated PMNs, (2) the capacity of the granulocytes of patients with chronic granulomatous disease (CGD) to produce TXB2, and finally (3) the generation of oxygen radicals in PMNs stimulated to produce TXB2 by the enzyme… CONTINUE READING