The role of reactive oxygen species and oxidative stress in mediating particulate matter injury.

@article{Xia2006TheRO,
  title={The role of reactive oxygen species and oxidative stress in mediating particulate matter injury.},
  author={Tian Xia and Michael Kovochich and Andr{\'e} E Nel},
  journal={Clinics in occupational and environmental medicine},
  year={2006},
  volume={5 4},
  pages={817-36}
}
Numerous reports link oxidative stress to particulate matter (PM)-induced adverse health effects. Increasing evidence is being collected that reactive oxygen species and oxidative stress are involved in PM-mediated injury. The physical characteristics and the chemical composition of PM play a key role in reactive oxygen species generation in vitro and in vivo. According to the hierarchical oxidative stress hypothesis, antioxidant phase II enzymes protect against PM-induced inflammation and… CONTINUE READING

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