The role of reactive oxygen intermediates in the regulation of cytokine-induced ICAM-1 surface expression on endothelial cells.

@article{Mcmullen2000TheRO,
  title={The role of reactive oxygen intermediates in the regulation of cytokine-induced ICAM-1 surface expression on endothelial cells.},
  author={Curtis T Mcmullen and Elizabeth C. Fleming and Grace Clarke and Marilyn Ann Armstrong},
  journal={Molecular cell biology research communications : MCBRC},
  year={2000},
  volume={3 4},
  pages={231-7}
}
ICAM-1 upregulation by endothelial cells plays a pivotal role in many disease processes, but signalling mechanisms leading to increased expression are poorly understood. In the current study we investigated the regulatory capacity of reactive oxygen intermediates (ROIs) in ICAM-1 activation by stimulating endothelial cells with the pro-inflammatory cytokines IL-1 beta, TNF alpha, IFN gamma, IL-2, and IL-4 prior to antioxidant treatment. ICAM-1 was expressed constitutively and upregulated on… CONTINUE READING

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