The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells.

@article{MacDonald2008TheRO,
  title={The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells.},
  author={Michael J. MacDonald and Agnieszka Dobrzyń and James M. Ntambi and Scott W. Stoker},
  journal={Archives of biochemistry and biophysics},
  year={2008},
  volume={470 2},
  pages={153-62}
}
Pancreatic beta cell mitochondria convert insulin secretagogues into products that support insulin exocytosis. We explored the idea that lipids are some of these products formed from acyl group transfer out of mitochondria to the cytosol, the site of lipid synthesis. There are two isoforms of acetyl-CoA carboxylase, the enzyme that forms malonyl-CoA from which C(2) units for lipid synthesis are formed. We found that ACC1, the isoform seen in lipogenic tissues, is the only isoform present in… CONTINUE READING