The role of proteolysis in Alzheimer's disease.

  title={The role of proteolysis in Alzheimer's disease.},
  author={Nigel M Hooper and A J Trew and Edward T. Parkin and Anthony J. Turner},
  journal={Advances in experimental medicine and biology},
Alzheimer's disease is characterised by the progressive deposition of the 4 kDa beta-amyloid peptide (A beta) in extracellular senile plaques in the brain. A beta is derived by proteolytic cleavage of the amyloid precursor protein (APP) by various proteinases termed secretases. alpha-Secretase is inhibited by hydroxamate-based zinc metalloproteinase… CONTINUE READING