The role of protein kinase R in the interferon response.

  title={The role of protein kinase R in the interferon response.},
  author={Agnieszka Pindel and Anthony J. Sadler},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  volume={31 1},
The effects of interferons (IFNs) are mediated through the induction of around 2,000 IFN-stimulated gene (ISG) products. However, the majority of these ISGs do not directly instigate IFN-mediated states, such as the defining resistance to viral infection. Rather, most ISGs encode cell signaling molecules that enhance the responsiveness to pathogens, and systemically disseminate signals from localized sites of infection. Relatively few IFN effector proteins have been well characterized. The… CONTINUE READING

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