The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells.

@article{Stanwell1994TheRO,
  title={The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells.},
  author={C Stanwell and Andreas J. Gescher and Tracey D Bradshaw and George R. Pettit},
  journal={International journal of cancer},
  year={1994},
  volume={56 4},
  pages={585-92}
}
Bryostatin I is a natural product currently under clinical evaluation as an antitumor agent. Like the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) it activates protein kinase C (PKC). Bryostatin I inhibits the growth of the human-derived A549 lung and MCF-7 adenocarcinoma cell lines, but much more weakly than TPA. The hypotheses… CONTINUE READING