The role of protein conformational fluctuations in allostery, function, and evolution.


It is now well-known that proteins exist at equilibrium as ensembles of conformational states rather than as unique static structures. Here we review from an ensemble perspective important biological effects of such spontaneous fluctuations on protein allostery, function, and evolution. However, rather than present a thorough literature review on each… (More)
DOI: 10.1016/j.bpc.2011.05.020

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