The role of protease activity in ErbB biology.

  title={The role of protease activity in ErbB biology.},
  author={Carl P Blobel and Graham F Carpenter and Matthew Freeman},
  journal={Experimental cell research},
  volume={315 4},
Proteases are now recognized as having an active role in a variety of processes aside from their recognized metabolic role in protein degradation. Within the ErbB system of ligands and receptors, proteases are known to be necessary for the generation of soluble ligands from transmembrane precursors and for the processing of the ErbB4 receptor, such that its intracellular domain is translocated to the nucleus. There are two protease activities involved in the events: proteases that cleave within… CONTINUE READING

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