The role of prostaglandin synthetase in the rate depressant effects and narcosis caused by ethanol.

@article{Elmer1991TheRO,
  title={The role of prostaglandin synthetase in the rate depressant effects and narcosis caused by ethanol.},
  author={G I Elmer and Frank R. George},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={256 3},
  pages={1139-46}
}
Ethanol is proposed to exert its pharmacological effects by increasing membrane fluidity. Support for this hypothesis comes from strong correlations between in vitro effects of ethanol and pharmacological effects and genetic variation seen in vivo. Because arachidonate acid (AA) cascade is a membrane-bound system activated by disruptions in the cell membrane, it is possible that ethanol-induced membrane fluidization increases the formation of AA metabolites such as prostaglandins. The studies… CONTINUE READING