The role of prophylactic cranial irradiation for patients with small-cell lung cancer.

@article{Nakahara2018TheRO,
  title={The role of prophylactic cranial irradiation for patients with small-cell lung cancer.},
  author={Yoshiro Nakahara and Jiichiro Sasaki and Tomoya Fukui and Sakiko Otani and Satoshi Igawa and Kazushige Hayakawa and N. Masuda},
  journal={Japanese journal of clinical oncology},
  year={2018},
  volume={48 1},
  pages={26-30}
}
Small-cell lung cancer (SCLC) has a particular propensity to metastasize to the brain, affecting ~10% of SCLC patients at diagnosis, but may occur in more than 50% of 2-year survivors. Most cytotoxic drugs have limited ability to cross the blood-brain barrier, and the effectiveness of chemotherapy for brain metastasis is limited. Therefore, prophylactic… CONTINUE READING