The role of progranulin in diabetes and kidney disease

  title={The role of progranulin in diabetes and kidney disease},
  author={Bruna Bellincanta Nicoletto and Luis Henrique Santos Canani},
  booktitle={Diabetology & metabolic syndrome},
Progranulin (PGRN) is a cysteine rich secreted protein, expressed in epithelial cells, immune cells, neurons, and adipocytes. It was first identified for its growth factor-like properties, being involved in early embryogenesis and tissue remodeling, acting as an anti-inflammatory molecule. In the central nervous system, PGRN has neurotrophic and neuroprotective actions. There is also evidence of PGRN effects on cancer, contributing to tumor proliferation, invasion and cell survival. Recently… CONTINUE READING