The role of prognostic factors in assessing ‘high-risk’ subgroups of patients with chronic lymphocytic leukemia

@article{Kay2007TheRO,
  title={The role of prognostic factors in assessing ‘high-risk’ subgroups of patients with chronic lymphocytic leukemia},
  author={Neil E Kay and Susan O'brien and Andrew R. Pettitt and Stephan Stilgenbauer},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={1885-1891}
}
The management of chronic lymphocytic leukemia (CLL) has historically relied on ‘watchful waiting’ and palliative approaches to therapy. However, the course of disease is highly variable and a substantial proportion of patients with early-stage CLL develop rapidly progressive disease requiring therapy. In recent decades, numerous clinical and biological prognostic markers that are predictive of decreased survival outcomes, disease progression and/or resistance to therapy, and that may play a… CONTINUE READING
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