• Corpus ID: 8336992

The role of procalcitonin in adult patients with community-acquired pneumonia--a systematic review.

@article{Berg2012TheRO,
  title={The role of procalcitonin in adult patients with community-acquired pneumonia--a systematic review.},
  author={Peter Berg and Bjarne Orskov Lindhardt},
  journal={Danish medical journal},
  year={2012},
  volume={59 3},
  pages={
          A4357
        }
}
INTRODUCTION Promising results in relation to severity assessment and treatment of patients with community-acquired pneumonia (CAP) have recently been presented from the study of procalcitonin (PCT) levels in these patients. METHODS A systematic search in PubMed and the Cochrane Library was conducted. Articles in English, German and Swedish were searched to investigate the role of PCT in adults with CAP. RESULTS The most thoroughly studied topic is the prediction of complications and death… 
Procalcitonin and community-acquired pneumonia (CAP) in children.
Comparison of Serum Levels of Procalcitonin and C-Reactive Protein in Patients with Community Acquired Pneumonia and COPD Exacerbation
TLDR
Statistical differences in PCT levels that would differentiate CAP from acute exacerbation of COPD in the ED setting are found, but further studies are required to verify this finding.
Interleukin-6 and procalcitonin as biomarkers in mortality prediction of hospitalized patients with community acquired pneumonia
TLDR
Both IL-6 and PCI are significant for prediction of 30-day mortality in hospitalized patients with CAP, and Serum levels of IL6 correlate with major CAP scoring systems.
Serum Procalcitonin as a Biomarker for the Prediction of Bacterial Exacerbation and Mortality in Severe COPD Exacerbations Requiring Mechanical Ventilation
TLDR
Admission PCT levels have a prognostic importance in estimating hospital mortality among patients with severe COPDE, and a PCT level <0.25 ng/ml at the time of admission and during follow-up is suggestive of the absence of a bacterial cause of COPDE.
Procalcitonin for individualizing antibiotic treatment: an update with a focus on COVID-19
TLDR
An up-to-date overview of the use of PCT in different clinical settings and diseases is provided, including a discussion about its potential to improve the care of patients with coronavirus disease 2019 (COVID-19).
NEUMONÍA ADQUIRIDA DE LA COMUNIDAD EN ADULTOS. RECOMENDACIONES SOBRE SU ATENCIÓN
TLDR
Treatment with amoxicillin is recommended for outpatients under 65 year old and without comorbidities, for patients 65 years or more or with comor bidities amoxicilli-clavulanic/sulbactam, and for patients admitted to intensive care unit ampicillin-sulBactam plus clarithromycin is suggested.
The use of procalcitonin in the diagnosis of bone and joint infection: a systemic review and meta-analysis
TLDR
PCT may be more suitable as an aid for rule-in diagnosis rather than for exclusion of septic arthritis or osteomyelitis and that use of a lower cut-off value for serum PCT may improve its diagnostic performance.
Procalcitonin as a biomarker in equine chronic pneumopathies
TLDR
PCT in BALF does not seem to be a superior marker compared to established clinical markers, but PCT in plasma seems to be more promising and a greater number of samples should be evaluated in further studies.
Procalcitonin kinetics in the first 48 hours of ICU admission is associated with higher mortality in critically ill patients with community-acquired pneumonia in a setting of high HIV prevalence
TLDR
While positive bacterial cultures are more likely in patients with high admission PCT, this assay does not allow for decisions to be made on antimicrobial management and is of limited clinical utility in critically ill patients with a high HIV prevalence and CAP.
Serum Procalcitonin: An Independent Predictor of Clinical Outcome in Health Care-Associated Pneumonia
TLDR
High PCT on admission was strongly associated with ICU admission and 30-day mortality in HCAP patients, however, application of PCT alone seems to be limited to predicting outcomes.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 37 REFERENCES
Procalcitonin as a diagnostic tool in lower respiratory tract infections and tuberculosis
TLDR
Procalcitonin concentration is not a useful parameter for diagnosis of lower respiratory tract infections, however, compared to the control group, there were significantly elevated levels in patients with hospital-acquired pneumonia, community- Acquired pneumonia and acute exacerbation of chronic bronchitis below the current cut-off level, which should be further investigated.
Usefulness of procalcitonin levels in community-acquired pneumonia according to the patients outcome research team pneumonia severity index.
TLDR
While procalcitonin may have a role to predict the microbial etiology in patients with a low PSI score, in patients classified within high PSI risk classes, it is a prognostic marker rather than a predictor of etiology.
Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia
TLDR
Increased PCT from day 1 to day 3 in severe CAP is a poor prognosis factor, but a PCT level less than 0.95 ng/ml on day3 in intubated patients is associated with a favorable outcome.
Procalcitonin and severity of community-acquired pneumonia
TLDR
It is concluded that the more severe the community-acquired pneumonia, the higher is the positivity rate for procalcitonin, and the prognosis in procalCitonin-positive patients is worse than that in proCalcitonIn-negative patients.
Procalcitonin versus C-reactive protein for predicting pneumonia in adults with lower respiratory tract infection in primary care.
  • A. Holm, S. Pedersen, C. Pedersen
  • Medicine, Biology
    The British journal of general practice : the journal of the Royal College of General Practitioners
  • 2007
TLDR
Both procalcitonin >0.06 ng/ml and CRP > or =20 mg/l were associated with radiographic pneumonia, bacterial infection, and subsequent hospitalisation, but positive predictive values were too low for any of the two inflammatory markers to be of use in clinical practice.
Influence of Steroids on Procalcitonin and C-reactive Protein in Patients with COPD and Community-acquired Pneumonia
TLDR
In patients with COPD and CAP, the time courses over 7 days of PCT and CRP showed a nearly parallel decline compared to non-COPD patients with CAP, contrary to the induction phase, corticosteroids do not modify the time-dependent decay of P CT andCRP when the underlying infectious disease (CAP) is adequately treated.
Procalcitonin: Inflammatory Biomarker for Assessing the Severity of Community-Acquired Pneumonia – A Clinical Observation in Geriatric Patients
TLDR
Procalcitonin, more than the risk scores CRB- and CURB-65 evaluated to date, appears to be a promising parameter for assessing the severity of pneumonia in elderly patients to allow early detection of severe courses and initiation of suitable treatment.
...
1
2
3
4
...