The role of presynaptic receptors in the cardiovascular actions of N,N-di-n-propyldopamine in the cat and dog

@article{Massingham1980TheRO,
  title={The role of presynaptic receptors in the cardiovascular actions of N,N-di-n-propyldopamine in the cat and dog},
  author={Roy Massingham and Margarita L Dubocovich and Salomon Z. Langer},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1980},
  volume={314},
  pages={17-28}
}
Intravenous administration of N,N-di-n-propyldopamine (DPDA: 50 and 200 μg/kg/min, i. v.) produces hypotensive and bradycardic effects in anaesthetized cats and dogs. These effects were abolished by ganglionic blockade and antagonized by haloperidol or (SR)-sulpiride suggesting a neurogenic mechanism of action, mediated by specific dopamine receptors. The… CONTINUE READING