The role of prenylation in G-protein assembly and function.

  title={The role of prenylation in G-protein assembly and function.},
  author={Jan Higgins and Patrick J. Casey},
  journal={Cellular signalling},
  volume={8 6},
Heterotrimeric guanine nucleotide-binding regulatory proteins (G-proteins) are vital components of numerous signal transduction pathways, including sensory and hormonal response systems. G-proteins transduce signals from heptahelical transmembrane receptors to downstream effectors. The localization of a G-protein to the plasma membrane, as well as its interaction with the appropriate receptor and effector, are essential for its function. In addition, the association of a G-protein's subunits to… CONTINUE READING

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