The role of porphyrin chemistry in tumor imaging and photodynamic therapy.


In recent years several review articles and books have been published on the use of porphyrin-based compounds in photodynamic therapy (PDT). This critical review is focused on (i) the basic concept of PDT, (ii) advantages of long-wavelength absorbing photosensitizers (PS), (iii) a brief discussion on recent advances in developing PDT agents, and (iv) the various synthetic strategies designed at the Roswell Park Cancer Institute, Buffalo, for developing highly effective long-wavelength PDT agents and their utility in constructing the conjugates with tumor-imaging and therapeutic potential (Theranostics). The clinical status of certain selected PDT agents is also summarized (205 references).

DOI: 10.1039/b915149b

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Showing 1-3 of 3 references

Porphyrinbased multifunctional agentsd for tumor-imaging and therapy, in The Porphyrin Handbook, ed

  • M. Ethirajan, N. J. Patel, R. K. Pandey
  • 2010

Photophysics and Photochemistry, in Photodynamic Therapy in Advances in Photodynamic Therapy, ed

  • R. W. Redmond
  • 2008
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