The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis

@article{Caplan2001TheRO,
  title={The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis},
  author={Michael S. Caplan and Tamas Jilling},
  journal={Lipids},
  year={2001},
  volume={36},
  pages={1053-1057}
}
Dietary polyunsaturated fatty acid (PUFA) supplementation has been shown to reduce the incidence of necrotizing enterocolitis (NEC) in a recent randomized, controlled trial. These compounds are known to modulate the inflammatory cascade and to influence intestinal health in a variety of ways. Although the pathophysiology of NEC is not well understood, recent evidence suggests that platelet-activating factor (PAF) is a key endogenous mediator of intestinal necrosis in animals. Using a neonatal… CONTINUE READING
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