The role of poly(ADP-ribose) in the DNA damage signaling network.

  title={The role of poly(ADP-ribose) in the DNA damage signaling network.},
  author={Maria Malanga and Felix R. Althaus},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={83 3},
DNA damage signaling is crucial for the maintenance of genome integrity. In higher eukaryotes a NAD+-dependent signal transduction mechanism has evolved to protect cells against the genome destabilizing effects of DNA strand breaks. The mechanism involves 2 nuclear enzymes that sense DNA strand breaks, poly(ADP-ribose) polymerase-1 and -2 (PARP-1 and PARP-2). When activated by DNA breaks, these PARPs use NAD+ to catalyze their automodification with negatively charged, long and branched ADP… CONTINUE READING
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Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins

  • J. M. Pleschke, H. E. Kleczkowska, M. Strom, F. R. Althaus
  • J. Biol. Chem. 275: 40 974–40 980.
  • 2000
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