The role of podoplanin in tumor progression and metastasis.

@article{Raica2008TheRO,
  title={The role of podoplanin in tumor progression and metastasis.},
  author={Marius Raica and Anca Maria C{\^i}mpean and Domenico Ribatti},
  journal={Anticancer research},
  year={2008},
  volume={28 5B},
  pages={
          2997-3006
        }
}
In the last decade, much data has been generated concerning the molecular mechanisms of lymphangiogenesis and its significance in pathological conditions. This was mainly due to the discovery of lymphatic endothelial cell (LEC)-specific markers, such as vascular endothelial growth factor receptor-3 (VEGFR-3), LYVE-1, Prox-1 and podoplanin. Podoplanin, originally detected on the surface of podocytes, belongs to the family of type-1 transmembrane sialomucin-like glycoproteins. Although specific… CONTINUE READING

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