The role of platelets in the pathogenesis of cerebral malaria

  title={The role of platelets in the pathogenesis of cerebral malaria},
  author={Dermot Cox and S Mcconkey},
  journal={Cellular and Molecular Life Sciences},
Malaria is a major cause of morbidity and mortality in the developing world and cerebral malaria is responsible for the majority of malaria-associated deaths. There is a strong association between thrombocytopenia and outcome in malaria, suggesting a role for platelets in the pathogenesis of malaria. This thrombocytopenia is likely due to platelet activation possibly through an interaction between PfEMP1 on plasmodium and CD36 on platelets. Platelet activation by plasmodium has two potential… CONTINUE READING

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