The role of platelets in acute kidney injury

  title={The role of platelets in acute kidney injury},
  author={Marcel P. B. Jansen and Sandrine Florquin and Joris J. T. H. Roelofs},
  journal={Nature Reviews Nephrology},
Acute kidney injury (AKI), a major public health problem associated with high mortality and increased risk of progression towards end-stage renal disease, is characterized by the activation of intra-renal haemostatic and inflammatory processes. Platelets, which are present in high numbers in the circulation and can rapidly release a broad spectrum of bioactive mediators, are important acute modulators of inflammation and haemostasis, as they are the first cells to arrive at sites of acute… CONTINUE READING
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