The role of platelet-derived growth factor receptor in eotaxin signaling of eosinophils.

@article{Adachi2006TheRO,
  title={The role of platelet-derived growth factor receptor in eotaxin signaling of eosinophils.},
  author={Tetsuya Adachi and Satoko Hanaka and Tomoko Elizabeth Yano and Koichi Yamamura and Hisanao Yoshihara and Hiroyuki Nagase and Junichi Chihara and Ken Ohta},
  journal={International archives of allergy and immunology},
  year={2006},
  volume={140 Suppl 1},
  pages={28-34}
}
BACKGROUND Receptor tyrosine kinases (RTKs) such as epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) are capable of eliciting kinase activity after ligand binding. In several cells, RTKs are activated via the G-protein-coupled receptor independent of the ligand-RTK interaction. We have previously found that EGFR is transactivated via CC chemokine receptor 3 in bronchial epithelial cells and that this pathway is important for mitogen-activated protein… CONTINUE READING