The role of platelet cyclooxygenase and lipoxygenase pathways in tumor cell induced platelet aggregation.

@article{Honn1987TheRO,
  title={The role of platelet cyclooxygenase and lipoxygenase pathways in tumor cell induced platelet aggregation.},
  author={Kenneth V. Honn and Bruce W. Steinert and Kamiar Moin and James M. Onoda and John Eric Taylor and Bonnie F Sloane},
  journal={Biochemical and biophysical research communications},
  year={1987},
  volume={145 1},
  pages={
          384-9
        }
}

• Kenneth V. Honn, Bruce W. Steinert, +3 authors Bonnie F Sloane
• Published in
  Biochemical and biophysical research…
  1987

Walker 256 carcinosarcoma cells induce the aggregation of rat platelets and concomitant production of eicosanoid metabolites (e.g., 12-hydroxyeicosatetraenoic acid, thromboxane A2). Cyclooxygenase inhibitors, but not lipoxygenase inhibitors, were able to inhibit platelet aggregation induced in vitro by low concentrations of agonists. At high agonist concentrations, neither cyclooxygenase nor lipoxygenase inhibitors affected platelet aggregation; however the combination of both inhibitors… CONTINUE READING

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