The role of pili and capsule in the pathogenesis of neonatal infection with Escherichia coli K1.

@article{Guerina1983TheRO,
  title={The role of pili and capsule in the pathogenesis of neonatal infection with Escherichia coli K1.},
  author={Nicholas G. Guerina and T Woodrow Kessler and Victoria J Guerina and Marian R. Neutra and Herbert William Clegg and Solomon Langermann and F. Scannapieco and Donald A. Goldmann},
  journal={The Journal of infectious diseases},
  year={1983},
  volume={148 3},
  pages={
          395-405
        }
}
The role of pili and capsule was studied in neonatal infection with Escherichia coli K1. E coli strains were selectively cultured into three phases: mannose-sensitive (MS) piliated, non-mannose-sensitive (NMS) piliated, and nonpiliated. A high percentage of neonatal rats fed each phase of K1 strains developed bacteremia; there was no bacteremia with non-K1 strains or an acapsular mutant of K1 strain C94 (C94K-). Oral cavity colonization was noted in nearly 100% of rats fed K1 strains, non-K1… CONTINUE READING
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