The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat.

@article{Kawakami1997TheRO,
  title={The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat.},
  author={Mamoru Kawakami and Tetsuya Tamaki and Hiroshi Hashizume and James N. DO Weinstein and Stephen T. Meller},
  journal={Spine},
  year={1997},
  volume={22 10},
  pages={1074-9}
}
STUDY DESIGN To elucidate the pathomechanisms of radicular pain secondary to lumbar disc herniation. OBJECTIVES To evaluate whether intervertebral disc material applied to the sciatic nerve produces hyperalgesia, and if the hyperalgesia in influenced by inhibitors of phospholipase A2 and nitric oxide synthase. SUMMARY OF BACKGROUND DATA Previously, the authors reported that application of nucleus pulposus and anulus fibrosus material to the lumbar epidural space produces different forms of… CONTINUE READING

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