The role of phosphoglycans in the susceptibility of Leishmania mexicana to the temporin family of anti-microbial peptides.

@article{Eggimann2015TheRO,
  title={The role of phosphoglycans in the susceptibility of Leishmania mexicana to the temporin family of anti-microbial peptides.},
  author={Gabriela A Eggimann and Kathryn Sweeney and Hannah L Bolt and Neshat Rozatian and Steven L. Cobb and Paul W Denny},
  journal={Molecules},
  year={2015},
  volume={20 2},
  pages={2775-85}
}
Natural product antimicrobial peptides (AMPs) have been proposed as promising agents against the Leishmania species, insect vector borne protozoan parasites causing the neglected tropical disease leishmaniasis. However, recent studies have shown that the mammalian pathogenic amastigote form of L. mexicana, a causative agent of cutaneous leishmaniasis, is resistant to the amphibian-derived temporin family of AMPs when compared to the insect stage promastigote form. The mode of resistance is… CONTINUE READING
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