The role of phosphatidic acid in the regulation of the Ras/MEK/Erk signaling cascade.

@article{Andresen2002TheRO,
  title={The role of phosphatidic acid in the regulation of the Ras/MEK/Erk signaling cascade.},
  author={Bradley T. Andresen and Mark A Rizzo and Kuntala Shome and Guillermo G. Romero},
  journal={FEBS letters},
  year={2002},
  volume={531 1},
  pages={65-8}
}
Phosphatidic acid (PA) is an important second messenger produced by the activation of numerous cell surface receptors. Recent data have suggested that PA regulates multiple cellular processes. This review addresses primarily the role of PA in the regulation of the Erk1/2 cascade pathway. A model for the regulation of Erk1/2 phosphorylation by cell surface receptors is presented. According to this model, agonists stimulate the binding of GTP to Ras and the activation of phospholipase D to… CONTINUE READING

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