The role of phenylalanine hydroxylase in melanotic encapsulation of filarial worms in two species of mosquitoes.

@article{Infanger2004TheRO,
  title={The role of phenylalanine hydroxylase in melanotic encapsulation of filarial worms in two species of mosquitoes.},
  author={Li-Chun Infanger and Thomas A. Rocheleau and Lyric C. Bartholomay and Jody K Johnson and Jeremy F. Fuchs and Stephen T Higgs and Cheng-Chen Chen and Bruce M. Christensen},
  journal={Insect biochemistry and molecular biology},
  year={2004},
  volume={34 12},
  pages={1329-38}
}
Melanin formation has a significant influence on mosquito vector competence by limiting the development of metazoan parasites. Tyrosine, the rate-limiting substrate of melanin production, can be obtained exogenously or derived from phenylalanine by phenylalanine hydroxylase (PAH). The characteristics of this defense mechanism, such as temporal expression of constituent enzymes involved in the biosynthetic pathway, can vary considerably between mosquito species. We investigated the functional… CONTINUE READING

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