The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

@article{Nagai2009TheRO,
  title={The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.},
  author={Yoshio Nagai and Shin Yonemitsu and Derek M. Erion and Takanori Iwasaki and Romana Stark and Dirk Weismann and Jianying Dong and Dongyan Zhang and Michael J Jurczak and Michael G. L{\"o}ffler and James Cresswell and Xing Xian Yu and Susan F. Murray and Sanjay Bhanot and Brett P. Monia and Jonathan S Bogan and Varman T Samuel and Gerald I Shulman},
  journal={Cell metabolism},
  year={2009},
  volume={9 3},
  pages={252-64}
}
Peroxisome proliferator-activated receptor gamma coactivator-1 beta (PGC-1beta) is known to be a transcriptional coactivator for SREBP-1, the master regulator of hepatic lipogenesis. Here, we evaluated the role of PGC-1beta in the pathogenesis of fructose-induced insulin resistance by using an antisense oligonucletoide (ASO) to knockdown PGC-1beta in liver and adipose tissue. PGC-1beta ASO improved the metabolic phenotype induced by fructose feeding by reducing expression of SREBP-1 and… CONTINUE READING
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