The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

@article{Kawai2010TheRO,
  title={The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors},
  author={Taro Kawai and Shizuo Akira},
  journal={Nature Immunology},
  year={2010},
  volume={11},
  pages={373-384}
}
The discovery of Toll-like receptors (TLRs) as components that recognize conserved structures in pathogens has greatly advanced understanding of how the body senses pathogen invasion, triggers innate immune responses and primes antigen-specific adaptive immunity. Although TLRs are critical for host defense, it has become apparent that loss of negative regulation of TLR signaling, as well as recognition of self molecules by TLRs, are strongly associated with the pathogenesis of inflammatory and… CONTINUE READING
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