The role of passive transbilayer drug movement in multidrug resistance and its modulation.

@article{Eytan1996TheRO,
  title={The role of passive transbilayer drug movement in multidrug resistance and its modulation.},
  author={Gera D Eytan and Ronit Regev and Gal Oren and Yehuda G Assaraf},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 22},
  pages={12897-902}
}
The successful lowering of the intracellular concentration of multidrug resistance (MDR)-type drugs by P-glycoprotein (Pgp) relies on its ability to overcome the passive influx rate of each MDR-type drug. Thus, the aim of the present work was to study the effect of passive transbilayer drug movement on the multidrug resistance and its modulation. Fluorescence quenching studies indicated that whereas the Pgp substrate rhodamine 123 traverses an artificial lipid membrane with a lifetime of 3 min… CONTINUE READING

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