The role of pH and osmolarity in evoking the acetic acid-induced wiping response in a model of nociception in frogs

@article{Hamamoto2000TheRO,
  title={The role of pH and osmolarity in evoking the acetic acid-induced wiping response in a model of nociception in frogs},
  author={Darryl T. Hamamoto and Michael W Forkey and Wendy L. Davis and Keith C. Kajander and Donald A. Simone},
  journal={Brain Research},
  year={2000},
  volume={862},
  pages={217-229}
}
Acetic acid applied to the hindlimb of a frog evokes a vigorous wiping of the exposed skin. The aim of this study was to determine if acetic acid evokes this wiping response by decreasing subepidermal pH. Because acetic acid is hyperosmolar, a second aim was to determine if the osmolarity of acetic acid contributed to evoking the wiping response. In behavioral experiments, different acids or acetic acid/sodium acetate buffers at different pHs were used to evoke the wiping response. In separate… Expand
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