The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation.

@article{Gaebele2005TheRO,
  title={The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation.},
  author={Erwin Gaebele and Shimon Reif and Shigeki Tsukada and Ram{\'o}n Bataller and Yutaka Yata and Terry Morris and Laura W. Schrum and David Brenner and Richard A. Rippe},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 14},
  pages={13374-82}
}
During fibrosis the hepatic stellate cell (HSC) undergoes a complex activation process characterized by increased proliferation and extracellular matrix deposition. The 70-kDa ribosomal S6 kinase (p70S6K) is activated by mitogens, growth factors, and hormones in a phosphatidylinositol 3-kinase-dependent manner. p70S6K regulates protein synthesis… CONTINUE READING