The role of p53-target genes in human cancer.

  title={The role of p53-target genes in human cancer.},
  author={Takashi Tokino and Yasuyuki Nakamura},
  journal={Critical reviews in oncology/hematology},
  volume={33 1},
The tumor suppressor gene p53 is mutated in a large proportion of human cancers. In some cellular conditions like DNA damage, the p53 gene is induced and its gene product is posttranscriptionally activated. p53 works as a transcriptional activator and induces the expression of its downstream target genes. This review will explain why expression of the normal p53 gene leads to tumor growth suppression. The p53 has several biological effects involving cell-cycle arrest, DNA replication and repair… CONTINUE READING
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