The role of p53 in tumour suppression: lessons from mouse models

  title={The role of p53 in tumour suppression: lessons from mouse models},
  author={Laura Attardi and Tyler 8 Jacks},
  journal={Cellular and Molecular Life Sciences CMLS},
The use of mouse models has greatly contributed to our understanding of the role of p53 in tumour suppression. Mice homozygous for a deletion in the p53 gene develop tumours at high frequency, providing essential evidence for the importance of p53 as a tumour suppressor. Additionally, crossing these knockout mice or transgenic expression p53 dominant negative alleles with other tumour-prone mouse strains has allowed the effect of p53 loss on tumour development to be examined further. In a… CONTINUE READING

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