Corpus ID: 35595608

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

@article{Merritt1994TheRO,
  title={The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.},
  author={A. Merritt and C. Potten and C. Kemp and J. Hickman and A. Balmain and D. Lane and P. Hall},
  journal={Cancer research},
  year={1994},
  volume={54 3},
  pages={
          614-7
        }
}
Three h after whole-body irradiation (8 Gy) of C57BL x DBA/2 F1 mice, p53 protein was expressed strongly in the stem cell compartment of the small intestine but at lower levels in the colon. At this time, apoptotic cells were also observed in the stem cell position of the small intestine, with fewer in the colon. In mice without copies of the p53 gene (nulls), the levels of spontaneous apoptosis, in both the small intestine and the colon, were not different from wild-type. Irradiation of the… Expand
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