The role of p53 in hypoxia-induced apoptosis.

  title={The role of p53 in hypoxia-induced apoptosis.},
  author={Ester M Hammond and Amato J. Giaccia},
  journal={Biochemical and biophysical research communications},
  volume={331 3},
Hypoxia represents one of the most physiologically relevant stresses, having significant roles in both normal development and malignant progression. Exposure to severe hypoxia leads to the accumulation of p53 which can in turn lead to rapid apoptosis. In contrast to the response to DNA-damaging agents, hypoxia-induced p53 has little or no transcriptional… CONTINUE READING