The role of p27(Kip1) phosphorylation at serine 10 in the migration of malignant glioma cells in vitro.

@article{Wang2011TheRO,
  title={The role of p27(Kip1) phosphorylation at serine 10 in the migration of malignant glioma cells in vitro.},
  author={Dong-lin Wang and Fei He and Li-sheng Zhang and Fengrui Zhang and Qi-zhi Wang and Xiaoxiao Qian and Xiaorong Pan and Jiao Meng and Chao Peng and Aiguo Shen and Jiajia Chen},
  journal={Neoplasma},
  year={2011},
  volume={58 1},
  pages={65-73}
}
Until recently, Cip/Kip members were almost solely viewed as nuclear proteins with a principal function of inhibiting cyclin/cyclin dependent kinase (CDK) activity and hence, inhibiting cell cycle progression. P27(Kip1) (hereafter p27) belongs to the Cip/Kip family that binds and inhibits all the cyclin/CDK complexes, thus often referred as a universal CDK inhibitor. However, emerging studies now suggest that Cip/Kip proteins play additional roles outside of the nucleus. Indeed, previous… CONTINUE READING
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