The role of p21cip1 in adaptation of CHO cells to suspension and protein-free culture.

@article{Astley2007TheRO,
  title={The role of p21cip1 in adaptation of CHO cells to suspension and protein-free culture.},
  author={Kelly Astley and Mariam Naciri and Andrew J Racher and Mohamed Al-Rubeai},
  journal={Journal of biotechnology},
  year={2007},
  volume={130 3},
  pages={282-90}
}
The up-regulation of cyclin-dependent kinase inhibitor p21 has been shown to enhance productivity of monoclonal antibodies and has been linked to various regulatory processes. To identify the potential role of p21 in adaptation to suspension and protein-free cultures, we studied the survival and growth of anchorage- and serum-dependent CHO cell lines that… CONTINUE READING