The role of oxytocin and oxytocin receptor gene variants in childhood‐onset aggression

@article{Malik2012TheRO,
  title={The role of oxytocin and oxytocin receptor gene variants in childhood‐onset aggression},
  author={Ayesha I Malik and Clement C. Zai and Z. Md. Abu and Behdin Nowrouzi and Joseph H. Beitchman},
  journal={Genes},
  year={2012},
  volume={11}
}
Aggressive antisocial behaviours are the most common reasons why adolescents are referred to mental health clinics. Antisocial behaviours are costly in social and financial terms. The aetiology of aggressive behaviours is unknown but growing evidence suggests it is heritable, and certain genetic variants have been implicated as contributing factors. The purpose of this study was to determine whether genes regulating the hormone oxytocin (OXT) were associated with aggressive antisocial behaviour… Expand
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TLDR
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References

SHOWING 1-10 OF 52 REFERENCES
Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition
TLDR
SNPs and haplotypes in the OXTR gene region identified using HapMap data and the Haploview algorithm show association with ASD, suggesting that this gene shapes both cognition and daily living skills that may cross diagnostic boundaries. Expand
Childhood aggression, callous-unemotional traits and oxytocin genes
TLDR
This is the first known study to show a significant association between callous-unemotional traits in children and adolescents with extreme, persistent pervasive aggression and a polymorphism on the oxytocin receptor. Expand
Dopaminergic system genes in childhood aggression: Possible role for DRD2
  • C. Zai, S. Ehtesham, +8 authors J. Beitchman
  • Psychology, Medicine
  • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2012
TLDR
The preliminary results suggest that three polymorphisms in DRD2 are associated with childhood aggression, and the relationship between the dopamine system and aggressive behaviour in children is explored. Expand
Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder
TLDR
Findings of association in a large independent cohort are consistent with previous results, and the biological plausibility of participation of the oxytocin signaling system in modulating social disruptions characteristic of ASD, suggest that functional polymorphisms of OXTR may contribute to ASD risk in a subset of families. Expand
Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults
TLDR
The present results suggest that OXTR might be associated with the susceptibility to ASD, especially in its aspects of social interaction and communication mediated by a modulation of amygdala development, one of the most distributed brain regions with high density of OX TR. Expand
Serotonin transporter polymorphisms and persistent, pervasive childhood aggression.
TLDR
This is the first study to report a significant association between the 5-HTTLPR gene and childhood aggression. Expand
Serotonin transporter promoter polymorphism genotype is associated with behavioral disinhibition and negative affect in children of alcoholics.
TLDR
Behaviors of undercontrol, which occur at increased rates in children of alcoholics, may be genetically influenced through the regulation of the 5-HT transporter. Expand
Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder
TLDR
CSF Oxytocin Levels were inversely correlated with life history of aggression, the first such report of a relationship between oxytocin levels and aggression, and the data are consistent with the known effects of oxytoc in on aggressive behavior in animals. Expand
Lower CSF oxytocin concentrations in women with a history of childhood abuse
TLDR
If replicated, the association of lower adult CSF OT levels with childhood trauma might indicate that alterations in central OT function may be involved in the adverse outcomes of childhood adversity. Expand
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
  • C. Carter
  • Medicine
  • Behavioural Brain Research
  • 2007
TLDR
Evidence for a role for two sexually dimorphic neuropeptides, oxytocin (OT) and arginine vasopressin (VP), in these features of ASD is considered. Expand
...
1
2
3
4
5
...