The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease.

@article{Miranda2000TheRO,
  title={The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease.},
  author={Soledad Miranda and Carlos Opazo and Luis F Larrondo and Francisco J Mu{\~n}oz and Francisca Martinez Ruiz and Federico M Leighton and Nibaldo C Inestrosa},
  journal={Progress in neurobiology},
  year={2000},
  volume={62 6},
  pages={633-48}
}
One of the theories involved in the etiology of Alzheimer's disease (AD) is the oxidative stress hypothesis. The amyloid beta-peptide (A beta), a hallmark in the pathogenesis of AD and the main component of senile plaques, generates free radicals in a metal-catalyzed reaction inducing neuronal cell death by a reactive oxygen species mediated process which damage neuronal membrane lipids, proteins and nucleic acids. Therefore, the interest in the protective role of different antioxidants in AD… CONTINUE READING

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