The role of oxidative stress in paraquat-induced neurotoxicity in rats: protection by non peptidyl superoxide dismutase mimetic.

@article{Mollace2003TheRO,
  title={The role of oxidative stress in paraquat-induced neurotoxicity in rats: protection by non peptidyl superoxide dismutase mimetic.},
  author={Vincenzo Mollace and Michelangelo Iannone and Carolina Muscoli and Emesto Palma and Teresa Granato and Vincenzo Rispoli and Robert Nistic{\'o} and Domenicoantonio Rotiroti and Daniela Salvemini},
  journal={Neuroscience letters},
  year={2003},
  volume={335 3},
  pages={163-6}
}
Herbicides, including paraquat, may produce neurodegenerative effect when given both peripherally and into the brain though the pathophysiological mechanism is still unknown. Microinfusion of paraquat into the Substantia Nigra (50 microg) produced increased motor activity, jumping and circling opposite to the injection site, associated with ECoG desynchronization, high voltage epileptogenic spikes, and with neuropathological effects. These effects were accompanied by increase of malondialdehyde… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…