The role of oxidative stress in carcinogenesis.


Chemical carcinogenesis follows a multistep process involving both mutation and increased cell proliferation. Oxidative stress can occur through overproduction of reactive oxygen and nitrogen species through either endogenous or exogenous insults. Important to carcinogenesis, the unregulated or prolonged production of cellular oxidants has been linked to… (More)


Cite this paper

@article{Klaunig2004TheRO, title={The role of oxidative stress in carcinogenesis.}, author={James E. Klaunig and Lisa M. Kamendulis}, journal={Annual review of pharmacology and toxicology}, year={2004}, volume={44}, pages={239-67} }