The role of oxidative stress in adult critical care.

  title={The role of oxidative stress in adult critical care.},
  author={Ettore Crimi and Vincenzo Sica and Sharon Williams-Ignarro and Haibo Zhang and Arthur S Slutsky and Louis Joseph Ignarro and Claudio Napoli},
  journal={Free radical biology & medicine},
  volume={40 3},
Oxidative stress defines an imbalance in production of oxidizing chemical species and their effective removal by protective antioxidants and scavenger enzymes. Evidence of massive oxidative stress is well established in adult critical illnesses characterized by tissue ischemia-reperfusion injury and by an intense systemic inflammatory response such as during sepsis and acute respiratory distress syndrome. Oxidative stress could exacerbate organ injury and thus overall clinical outcome. We… CONTINUE READING


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