The role of oxidative stress and innate immunity in O(3) and endotoxin-induced human allergic airway disease.

@article{Peden2011TheRO,
  title={The role of oxidative stress and innate immunity in O(3) and endotoxin-induced human allergic airway disease.},
  author={David B. Peden},
  journal={Immunological reviews},
  year={2011},
  volume={242 1},
  pages={
          91-105
        }
}
Ozone (O(3)) and endotoxin are common environmental contaminants that cause asthma exacerbation. These pollutants have similar phenotype response characteristics, including induction of neutrophilic inflammation, changes in airway macrophage immunophenotypes, and ability to enhance response to inhaled allergen. Evoked phenotyping studies of volunteers exposed to O(3) and endotoxin were used to identify the response characteristics of volunteers to these pollutants. New studies support the… CONTINUE READING
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