The role of oxidative stress and endothelial injury in diabetic neuropathy and neuropathic pain.


OBJECTIVE The roles of endothelin-1 (ET-1) and oxidative stress causing vascular injury in the pathogenesis of diabetic neuropathy are debatable. The present study was undertaken to clarify the possible effects of oxidative stress and ET-1 in diabetic patients with and without peripheric neuropathy. METHODS We studied plasma ET-1, nitric oxide (NO… (More)


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